Work

I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides

Year: 2014

Type: dissertation

Abstract: Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two helical turns in a peptide increase alpha-helical content and protease resistance, enhance target binding affinity, and promote cell penetration. This technology has been applied to the development of cell-permeable ligands targeting several intracellular targets. This dissertation describes efforts to further the development of stapled peptide technology.

Source: Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Author: Qian Chu

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2159248966

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