MicroRNA‐184 modulates canonical Wnt signaling through the regulation of frizzled‐7 expression in the retina with ischemia‐induced neovascularization
Year: 2015
Type: article
Abstract: Aberrant activation of Wnt signaling contributes to ischemia-induced retinal neovascularization in oxygen-induced retinopathy (OIR), although the underlying mechanism is so far unclear. Here, we show that microRNA-184 (miR-184) is significantly down-regulated in the retina of OIR mice, and miR-184 negatively modulates Wnt signaling both in vivo and in vitro. Furthermore, we show that the Wnt receptor, frizzled-7, is a downstream target of miR-184, and delivery of miR-184 mimic inhibits Wnt signaling in the OIR retina. These results suggest that decreased levels of miR-184 are responsible, at least in part, for the aberrant activation of Wnt signaling in ischemia-induced retinal neovascularization.
Source: FEBS Letters
Authors: Yusuke Takahashi, Qian Chen, Raju V.S. Rajala, Jian-xing Ma
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Funders: American Heart Association, International Retinal Research Foundation, Oklahoma Center for the Advancement of Science and Technology, Juvenile Diabetes Research Foundation United States of America, National Institutes of Health, University of Oklahoma Health Sciences Center, National Eye Institute, National Institute of General Medical Sciences
OpenAlex ID: W2159265947