Influence of age and sex and day-to-day and within-day biological variation on plasma concentrations of fatty acid-binding protein and myoglobin in healthy subjects.
Year: 1999
Type: letter
Abstract: Fatty acid-binding protein (FABP), like myoglobin (Mb), increases significantly within ∼3 h after onset of symptoms of acute myocardial infarction (AMI) and returns to health-related values within 12 to 24 h (1). For the early assessment or exclusion of AMI, FABP performs better than Mb (2)(3). Although FABP, like Mb, is also found in skeletal muscle, the distinct ratio of the contents of Mb over FABP in heart (ratio, 4–5) and skeletal muscle (ratio, 20–70) allows the discrimination between myocardial and skeletal muscle injury (4).
For the assessment of clinical reference values, it is important to know the possible influence of biological variations such as age, sex, and day-to-day and within-day fluctuations (5); however, for FABP such data are lacking. The aim of the present study was to establish these parameters for FABP first in a large group of volunteers of different ages. Mb was also measured to delineate possible effects of age and sex on the ratio of the plasma concentrations of Mb over FABP. We also studied day-to-day and within-day biologic variation (within-person) for both FABP and Mb concentrations in another group of volunteers.
For the first substudy, plasma samples were taken from 312 donors (110 women and 202 men; ages, 21–70 years) visiting the blood bank of Liege, Belgium. EDTA …
Source: PubMed
Institutions: University of Liège, Maastricht University
Language: English
Subfield: Medical Laboratory Technology
Field: Health Professions
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2159323782