Work

Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests

Year: 2009

Type: article

Abstract: Rauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety.

Source: Revista Brasileira de Farmacognosia

DOI: 10.1590/s0102-695x2009000600017

Authors: Sueli Mendonça Netto, Rogério W. B. Warela, Madge F. Fechine, Marcelo N. Queiroga, Lucindo J. Quintans-Júnior

Institutions: Universidade Federal de Juiz de Fora, Universidade Federal da Paraíba, Universidade Federal de Sergipe

Language: English

Topic: Medicinal Plant Extracts Effects

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,990