Work

Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?

Year: 2008

Type: article

Abstract: In Brief The activity of 5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle. We present evidence that elevated AMPK activity may partly underlie atrophy and diminished capacity for growth in aged fast-twitch muscle.

Source: Exercise and Sport Sciences Reviews

DOI: 10.1097/jes.0b013e3181877e13

Authors: Scott E. Gordon, Jordan A. Lake, Christopher M. Westerkamp, David M. Thomson

Institutions: East Carolina University, Brigham Young University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging