Work

Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis

Year: 2013

Type: article

Study design: Observational Study

Abstract: Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/cit715

Authors: Lucas R. Hoffman, Christopher E. Pope, Hillary S. Hayden, Sonya Heltshe, Roie Levy, Sharon McNamara, Michael A. Jacobs, Laurence Rohmer, Matthew Radey, Bonnie W. Ramsey, Mitchell J. Brittnacher, Elhanan Borenstein, Samuel I. Miller

Institutions: Seattle Children's Hospital, Santa Fe Institute, University of Washington

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G308544354, Pseudomonas Aeruginosa Early CF Adaptive Changes: A Translational Study, Center for Cystic Fibrosis Translational Research in the Post-CFTR modulator Era

OpenAlex ID: W2159649357

FWCI: 2.554

Cites: 13

Cited by: 109

Related to: 10