The maintenance of genetic variability by mutation in a polygenic character with linked loci
Year: 1975
Type: article
Abstract: SUMMARY It is assumed that a character under stabilizing selection is determined genetically bynlinked, mutable loci with additive effects and a range of many possible allelic effects at each locus. A general qualitative feature of such systems is that the genetic variance for the character is independent of the linkage map of the loci, provided linkage is not very tight. A particular detailed model shows that certain aspects of the genetic system are moulded by stabilizing selection while others are selectively neutral. With reference to experimental data on characters ofDrosophilaflies, maize, and mice, it is concluded that large amounts of genetic variation can be maintained by mutation in polygenic characters even when there is strong stabilizing selection. The properties of the model are compared with those of heterotic models with linked loci.
Source: Genetics Research
Author: Russell Lande
Institution: Harvard University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funder: National Science Foundation
OpenAlex ID: W2159707462