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Sestrins at the crossroad between stress and aging

Year: 2010
Type: article
Abstract: Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
Source: Aging
DOI: 10.18632/aging.100157
Language: English
Subfield: Aging
Open Access status: hybrid
Funders: National Science Foundation, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
Awards: G1025129752, G1113543863, G1470758826, G1820179381, G387047875, G3874277843, G5159938335, Analysis of Wing Vein Specification in Drosophila, Molecular Genetics of Early Neurogenesis, G7117705659, G7924620364, G850990031, G9000030100, G9000076190, G9000280788, G9000282900, G9000342542
OpenAlex ID: W2159830316
FWCI: 1.45
Cites: 61
Cited by: 64
Related to: 10