Work

Sequential CH Arylation and Olefination: Total Synthesis of the Proposed Structure of Pipercyclobutanamide A

Year: 2012

Type: article

Abstract: Hip to be square: A strategy for assembling tetrasubstituted cyclobutanes is reported in the context of a short, protecting-group-free synthesis of the proposed structure of pipercyclobutanamide A. The route features sequential CH functionalizations on an unactivated cyclobutane wherein CC bonds to aryl and styryl groups are made one by one in a stereocontrolled fashion. DG=directing group.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201203897

Authors: Will R. Gutekunst, Ryan Gianatassio, Phil S. Baran

Institution: Scripps Research Institute

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Synthesis of Pyrrole-Imidazole Alkaloids, G963544812