Work

Role of Klebsiella pneumoniae LamB Porin in Antimicrobial Resistance

Year: 2011

Type: article

Abstract: To investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various antibiotics and the frequency of mutation to increased cefoxitin or meropenem resistance of the strains CSUB10S (expressing only OmpK36), CSUB10R (lacking OmpK35 and OmpK36), and their derived isogenic insertion-duplication mutants deficient in LamB. Expression of LamB was indispensable in order for CSUB10S to lose OmpK36 and become resistant to cefoxitin, while in CSUB10R, LamB deficiency promoted increased resistance to carbapenem.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01441-10

Authors: Laura García-Sureda, Carlos Juan, Antonio Doménech-Sánchez, Sebastián Albertí

Institutions: Consejo Superior de Investigaciones Científicas, Mediterranean Institute for Advanced Studies, Universitat de les Illes Balears, Hospital Universitario Son Dureta, Universidad de Sevilla

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Ciencia y Tecnología, Instituto de Salud Carlos III