Work

Generation of antigen-specific T cell immunity through T cell receptor gene transfer

Year: 2009

Type: dissertation

Abstract: Cancer cells often escape the attack of immune cells because they originate from self-tissue. Through T cell receptor gene transfer it is possible to equip peripheral T cells with a desired specificity, and this strategy may be useful to generate tumor-specific T cells for the treatment of cancer in humans. This thesis describes several aspects in the functionality, safety and longevity of T cells modified by T cell receptor gene transfer in animal models.

Source: Leiden Repository (Leiden University)

Author: Miriam Coccoris

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

OpenAlex ID: W2160138740

Cites: 132

Cited by:

Related to: 10