Year: 2000
Type: article
Abstract: A causal association between endogenous and exogenous estrogens and breast cancer development has been established [ 6 , 8 , 9 ]. Variant alleles of candidate genes involved in steroid hormone production (eg CYP17 , CYP19 and 17β -HSD ) [ 7 , 10 , 11 , 12 , 13 ] and polymorphic variants in steroid hormone receptors (eg ERα , PR and AR ) [ 14 , 15 , 16 , 17 ] are currently being evaluated as potential high prevalence, low penetrance markers of breast cancer risk. Women with biologically functional polymorphisms in these genes may be exposed to increased levels of circulating steroid hormones or enhanced activity of hormone-responsive genes, and thus have altered susceptibility to steroid hormone-associated cancers.
Source: Breast Cancer Research
DOI: 10.1186/bcr82
Authors: Christopher A Haiman, Susan E Hankinson, Donna Spiegelman, Graham A Colditz, Walter C Willett, Frank E Speizer, Myles Brown, David J Hunter
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Awards: A PROSPECTIVE STUDY OF DIET AND CANCER IN WOMEN, G151562090, Cohort Study of Genetic Susceptibility to Breast Cancer, Biochemical Markers in the nurses' Health Study Cohort, G37846424, G459566519, G4666650047, G5483112348, FUNCTIONS OF ESTROGEN RECEPTOR ASSOCIATED PROTEINS, Biochemical Markers in the Nurses? Health Study Cohort, G9000028950, G9000197069
OpenAlex ID: W2160285392