Work

Sumoylation of Vimentin354 Is Associated with PIAS3 Inhibition of Glioma Cell Migration

Year: 2010

Type: article

Abstract: The invasive phenotype of glioblastoma multiforme (GBM) is a hallmark of malignant process, yet the molecular mechanisms that dictate this locally invasive behavior remain poorly understood. Over-expression of PIAS3 effectively changes cell shape and inhibits GBM cell migration. We focused on the molecular target(s) of PIAS3 stimulated sumoylation, which play an important role in the inhibition of GBM cell motility. Here we report, through the immunoprecipitation with SUMO1 antibody, followed by proteomic analysis, the identification of vimentin (vimentin354), a nuclear component in GBM cells, as the main target of sumoylation promoted by PIAS3.

Source: Oncotarget

DOI: 10.18632/oncotarget.196

Authors: Liming Wang, Jian Zhang, Sipra Banerjee, Laura Barnes, Venkateswara Sajja, Yiding Liu, Baochuan Guo, Yuping Du, Mukesh K. Agarwal, David N. Wald, Qin Wang, Jinbo Yang

Institutions: Cleveland Clinic, Cleveland Clinic Research, Lanzhou University, Tartis (United States), Cleveland State University, Case Western Reserve University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cleveland Clinic, Cleveland Clinic Foundation, Ministry of Science and Technology of the People's Republic of China, National Institutes of Health, Program for New Century Excellent Talents in University, National Human Genome Research Institute, National Cancer Institute

Awards: G186742953, G2242648650, DEVELOPMENT OF MALDI-TOF FOR DNA SEQUENCING TECHNOLOGIES, MALDI TOF TECHNOLOGY FOR MOLECULAR ANALYSIS OF CANCER, MALDI TOF TECHNOLOGY FOR MOLECULAR ANALYSIS OF CANCER, G44698586

OpenAlex ID: W2160292692

FWCI: 1.356

Cites: 29

Cited by: 46

Related to: 10