Work

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

Year: 1999

Type: article

Abstract: Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium tuberculosis develop a granuloma-like lesion in which NKT cells are predominant. NKT cells play a primary role in the granulomatous response, because the latter does not occur in Jalpha281(-/-) mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible for the recruitment of NKT cells; the recruiting activity is associated with fractions containing phosphatidylinositolmannosides. These results define a powerful experimental set up for studying the in vivo induction of NKT cell responses to microbial components.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.96.9.5141

Authors: I. Apostolou, Y. Takahama, C. Belmant, T. Kawano, M. Huerre, G. Marchal, J. Cui, M. Taniguchi, H. Nakauchi, J.-J. Fournié, P. Kourilsky, G. Gachelin

Institutions: Inserm, Institut Pasteur

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2160420882

FWCI: 16.03

Cites: 44

Cited by: 198

Related to: 10