Work

1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson–Crick base pairs for DNA sequencing by electron tunneling

Year: 2012

Type: article

Abstract: With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A : T and G : C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c2ob26529j

Authors: Feng Liang, Stuart Lindsay, Peiming Zhang

Institution: Arizona State University

Language: English

Topic: Molecular Junctions and Nanostructures

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funder: National Human Genome Research Institute

Awards: G1960102365, Sequencing by Recognition