Work

From discrete to continuous and back: Abstractions and mesoscopic phenomena in cells

Year: 2008

Type: conference-paper

Abstract: We discuss the interplay between stochasticity and multistability in bio-molecular networks. The resulting cell-level stochastic behavior reflects the fundamentally discrete and random nature of the underlying molecular processes. These ideas are illustrated on the well studied example of the lac operon. We first describe the switching behavior predicted by a differential-equation based model and then show how cell-level stochastic behavior emerges. Finally we point out that the observed macroscopic behavior may not be enough to determine both the dynamic and stochastic parameters.

Source: International Workshop on Discrete Event Systems

DOI: 10.1109/wodes.2008.4605958

Authors: Adam M. Halasz, Julius A. Agung, George Pappas, Vijay Kumar

Institution: University of Pennsylvania

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Defense Advanced Research Projects Agency

OpenAlex ID: W2160513018

FWCI: 1.044

Cites: 8

Cited by: 1

Related to: 10