Work

In vivo Photoacoustic Tomography of Total Blood Flow and Potential Imaging of Cancer Angiogenesis and Hypermetabolism

Year: 2012

Type: article

Abstract: Blood flow is a key parameter in studying cancer angiogenesis and hypermetabolism. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. However, the Doppler angle (beam-to-flow angle) is needed to calculate the total flow speed, and it cannot always be estimated accurately in practice, especially when the system's axial and lateral resolutions are different. To overcome this problem, we propose a method to compute the total flow speed and Doppler angle by combining the axial and transverse flow measurements. The method has been verified by flowing bovine blood in a plastic tube at various speeds and Doppler angles. The error was experimentally determined to be less than 0.3 mm/s for total flow speed, and less than 158 for the Doppler angle. In addition, the method was tested in vivo on a mouse ear. We believe that the proposed method has the potential to be used for cancer angiogenesis and hypermetabolism imaging.

Source: Technology in Cancer Research & Treatment

DOI: 10.7785/tcrt.2012.500278

Authors: Junjie Yao, Konstantin I. Maslov, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering