IGF-I Bioactivity in Aging, Health and Disease
Year: 2010
Type: dissertation
Abstract: The existence of insulin-like growth factors (IGFs) in blood was fi rst recognized \nby Wiliam D. Salmon Jr. and Wiliam H. Daughaday in 1956. Examining \nthe role of pituitary-regulated growth-stimulating substances, these \nauthors demonstrated that a growth hormone (GH) dependent factor in serum \ncould stimulate labeled sulfate (35SO4) incorporation into chondroitin sulfate \n(cartilage) in vitro. In line with their fi ndings, Salmon and Daughaday initially \ndesignated this factor as ‘sulfation factor’. Comparative studies were also \nperformed in vivo. Hypophysectomy of rats markedly reduced labeled sulfate \nincorporation into chondroitin sulfate of epiphyseal cartilage, whereas injections \nof pituitary extracts and purifi ed bovine GH effectively restored 35SO4 \nincorporation. The observations that the direct effect of bovine GH on \ncostal cartilage was minimal, whereas serum from hypophysectomized rats \ntreated with bovine GH stimulated 3H-thymidine incorporation into cartilage \nled to the postulation that GH utilized the intermediary substance sulfation \nfactor.
Author: Michael P. Brugts
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2160562466