Work

Targeting Metabolic Scavenging in Pancreatic Cancer

Year: 2013

Type: article

Abstract: Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-13-2570

Authors: Costas A. Lyssiotis, Lewis C. Cantley

Institution: Weill Cornell Medicine

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute