Work

Combination Echinocandin-Polyene Treatment of Murine Mucormycosis

Year: 2008

Type: article

Abstract: We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01458-07

Authors: Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Yue Fu, John E. Edwards, Brad Spellberg

Institutions: University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Pfizer, Gilead Sciences, Astellas Pharma, National Institute of Allergy and Infectious Diseases