Work

Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis

Year: 2013

Type: review

Abstract: Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.

Source: BioMed Research International

DOI: 10.1155/2013/389537

Authors: James H. Tabibian, Jayant A. Talwalkar, Keith D. Lindor

Institutions: Mayo Clinic, Arizona State University

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680