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Synthesis and Cytotoxicity Screening of Some Novel Benzofuranoyl-pyrazole Derivatives against Liver and Cervix Carcinoma Cell Lines

Year: 2009

Type: article

Abstract: A series of new pyrazole, thiazole and thiazolinone derivatives incorporated into benzofuran were synthesized by using 3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-carboxaldehyde as starting material. A total of 41 novel compounds were synthesized. Some of these synthesized compounds were evaluated for cytotoxicity activity against HEPG2 (liver carcinoma cell line) and HELA (cervix carcinoma cell line). The tested compounds (1, 2c, 7c, 8b, 9b, 13b and 14b) showed better activities at low concentration against the commonly used human carcinoma cell lines. A detailed synthesis, spectroscopic data and cytotoxicity screening for the new compounds are described.

Source: South African Journal of Chemistry

Authors: Magdy I. El‐Zahar, Somaia S. Abd El‐Karim, Manal M. Anwar

Institution: National Research Centre

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2160814958

FWCI:

Cites:

Cited by: 15

Related to: 10