Work

Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae

Year: 1999

Type: article

Abstract: An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.43.1.187

Authors: Martin J. Gill, Nigel P. Brenwald, Richard Wise

Institutions: Birmingham City Hospital, University of Birmingham

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2160852967

FWCI: 14.85

Cites: 14

Cited by: 258

Related to: 9