Effects of Vitamin D Supplementation on C-peptide and 25-hydroxyvitamin D Concentrations at 3 and 6 Months
Year: 2015
Type: article
Study design: Clinical Trial
Abstract: The link between African-Americans' disproportionate rates of diabetes, obesity and vitamin D deficiency may be marked by C-peptide as an indicator of insulin secretion. We hypothesize that vitamin D supplementation will increase C-peptide, a marker of insulin secretion. During 3 winters from 2007-2010, 328 healthy African-Americans (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. The differences in non-fasting C-peptide between baseline and 3 months were -0.44 ng/mL for those receiving placebo, -0.10 ng/mL for those receiving 1000 IU/d, 0 ng/mL for those receiving 2000 IU/d, 1.24 ng/mL for those receiving 4000 IU/d (C-peptide increased 0.42 ng/mL for each additional 1000 IU/d of vitamin D3, p < 0.001). Vitamin D supplementation increased C-peptide in overweight African-Americans and may be compatible with other recommendations for diabetes prevention and management including weight loss and increased physical activity.
Source: Scientific Reports
DOI: 10.1038/srep10411
Institutions: Brigham and Women's Hospital, Harvard University, Michigan State University, Duke University, Dana-Farber Cancer Institute, Massachusetts General Hospital, Medical University of South Carolina, Boston Children's Hospital, Dana-Farber/Harvard Cancer Center, Washington University in St. Louis
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: U.S. Department of Defense, Office of Dietary Supplements, Brigham and Women's Hospital, Pharmavite, Harvard University, Harvard Catalyst, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, DOD Prostate Cancer Research Program
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1460768082, G1470284823, G166012955, G1978278092, G2661966628, G2883192542, Community-based Obesity Prevention among Blacks, G3615943839, G3754462075, G520401124, G5406738972, G6424384527, Mentored Patient-Oriented Research in Digestive Diseases, G7060033699, G9000089438, G9000307188
OpenAlex ID: W2160874790