Lipid Microdomains in Insulin Receptor Signalling
Year: 2006
Type: dissertation
Abstract: 9 REVIEW OF THE LITERATURE 11 1. Cell membranes and cholesterol 11 1.1 Cellular membranes 11 1.1.1 Basic structure and components 11 1.1.2 Cholesterol-sphingolipid interaction 14 1.1.3 Distribution of cholesterol and other lipids in cell membranes 15 1.2 Cholesterol homeostasis in mammalian cells 16 1.2.1 Cholesterol biosynthesis, lipoprotein uptake and cholesterol efflux 16 1.2.2 Cholesterol esterification and lipid droplets 18 1.2.3 Regulation of cholesterol homeostasis 18 1.2.4 Intracellular cholesterol transport 20 1.2.5 Cholesterol metabolism in hepatocytes 20 1.3 The Niemann-Pick type C (NPC) proteins and disease 22 1.4 Other sterols in mammalian cells 23 2. Cholesterol-rich membrane domains, “lipid rafts” 24 2.1 Biophysical basis for domain formation 25 2.1.1 Phase behavior of membrane lipids 25 2.1.2 Domain formation in cholesterol-containing membranes 26 2.1.3 Detergent-resistant domains in cells and model membranes 26 2.2 The lipid raft hypothesis 27 2.2.1 Classicall views and methods for studying rafts 27 2.2.2 Caveolae and caveolins 29 2.2.3 Lipid rafts and other sterols 30 2.2.4 The size and properties of lipid rafts in cells 30 2.2.5 Current views of lipid rafts 32 2.2.4 Pitfalls in the traditional methods for studying rafts 32 2.3 Lipid rafts in signal transduction 33 3. Insulin receptor signaling and insulin resistance 35 3.1 Insulin target tissues 35
Source: Työväentutkimus Vuosikirja
Author: Saara Vainio
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2160953376