Work

Understanding the Rhythm of Breathing: So Near, Yet So Far

Year: 2011

Type: review

Abstract: Breathing is an essential behavior that presents a unique opportunity to understand how the nervous system functions normally, how it balances inherent robustness with a highly regulated lability, how it adapts to both rapidly and slowly changing conditions, and how particular dysfunctions result in disease. We focus on recent advancements related to two essential sites for respiratory rhythmogenesis: (a) the preBötzinger Complex (preBötC) as the site for the generation of inspiratory rhythm and (b) the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) as the site for the generation of active expiration.

Source: Annual Review of Physiology

DOI: 10.1146/annurev-physiol-040510-130049

Authors: Jack L. Feldman, Christopher A. Del Negro, Paul A. Gray

Institutions: University of California, Los Angeles, William & Mary, Washington University in St. Louis

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke