Work

Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

Year: 1999

Type: article

Abstract: The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.43.6.1500

Authors: Sunwen Chou, Nell S. Lurain, Adriana Weinberg, Guang-Yung Cai, Prem L. Sharma, Clyde S. Crumpacker

Institutions: Portland VA Medical Center, Rush University Medical Center, University of Colorado Health, Beth Israel Deaconess Medical Center

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases