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Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Middle-Aged and Elderly Japanese Men

Year: 2009

Type: article

Abstract: BACKGROUND: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. METHODS AND RESULTS: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). CONCLUSIONS: An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.

Source: Circulation Journal

DOI: 10.1253/circj.cj-08-0492

Authors: Noriko Inoue, Ryo Maeda, Hideshi Kawakami, Tomoki Shokawa, Hideya Yamamoto, Chikako Ito, Hideo Sasaki

Institutions: Hiroshima University, Research Institute for Radiation Biology and Medicine, Hiroshima University, Great Falls Clinic, Hiroshima Atomic Bomb Casualty Council

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2021523136

FWCI: 6.982

Cites: 27

Cited by: 103

Related to: 10