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Coagulopathy in cirrhosis – The role of the platelet in hemostasis

Year: 2013

Type: article

Abstract: Cirrhotic patients are at increased risk of bleeding, particularly gastrointestinal bleeding, as a consequence of portal hypertension and/or coagulopathy attributed to liver synthetic dysfunction. Paradoxically, they are also at risk of thrombosis, predominantly in the splanchnic circulation, especially when platelet counts are increased by transfusion or drug therapy [1,2]. A major problem in clinical practice is the inadequacy of coagulation tests, which do not predict bleeding or thrombotic events, but may result in the inappropriate administration of therapies (e.g., plasma transfusions prior to procedures).

Source: Journal of Hepatology

DOI: 10.1016/j.jhep.2013.03.040

Authors: Elliot B. Tapper, Simon C. Robson, Raza Malik

Institutions: Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Liver Disease and Transplantation

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,500