Work

RNA‐Selective Modification by a Platinum( II ) Complex Conjugated to Amino‐ and Guanidinoglycosides

Year: 2005

Type: article

Abstract: Revving up the RNA response: Binding of the anticancer drug cisplatin (cis-Pt) to nucleic acids is believed to favor DNA over RNA. To “reverse” the nucleic acid selectivity of cis-Pt, amino- and guanidinoglycoside–PtII conjugates (1 and 2) have been synthesized and evaluated. The conjugates generate site-specific, RNA-selective, covalent cross-links to the HIV-1 Rev response element.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200461182

Authors: Jürgen Boer, Kenneth F. Blount, Nathan W. Luedtke, Lev Elson‐Schwab, Yitzhak Tor

Institution: University of California San Diego

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G2001143725, Novel Approaches to the Discovery of Anti-HIV Agents, Enhancing RNA binding selectivity of guanidinoglycosides, G794960854