Response letter to comment on: Villareal et al. (2009) TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action. Diabetes; 59:479–485
Year: 2010
Type: article
Abstract: We appreciate Knop’s (1) interest in ourrecent article (2). Although his suggestionthat the impaired incretin response ob-served in subjects with the TCF7L2 variant rs7903146 may be due to insulin resistance and impaired glucose tolerance (IGT) is interesting, this hypothesis is not supported by our data. Insulin sensitivity was mea-sured in both groups using the oral glucose minimal model, which has been validated against the clamp technique (3), and no differences were found (14.2 vs. 15.3 103 min1 per pmol/l; P 0.42). Although there was a tendency toward a higher BMI in the group with the TCF7L2 variant, the difference did not reach statis-tical significance. We directly measured percent body fat by using the dual-energy X-ray absorptiometry tech-nique (4), and there were no significant differences between the control group and the TCF7L2 group (38.9 % vs. 38.2%, P 0.82). Thus, based on this accurate
Source: Diabetes
DOI: 10.2337/db10-0303
Authors: Dennis T. Villareal, Kenneth S. Polonsky
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2145824536