Work

Structure and Polymorphism of the UL6 Portal Protein of Herpes Simplex Virus Type 1

Year: 2004

Type: article

Abstract: By electron microscopy and image analysis, we find that baculovirus-expressed UL6 is polymorphic, consisting of rings of 11-, 12-, 13-, and 14-fold symmetry. The 12-mer is likely to be the oligomer incorporated into procapsids: at a resolution of 16 A, it has an axial channel, peripheral flanges, and fits snugly into a vacant vertex site. Its architecture resembles those of bacteriophage portal/connector proteins.

Source: Journal of Virology

DOI: 10.1128/jvi.78.22.12668-12671.2004

Authors: Benes L. Trus, Naiqian Cheng, William W. Newcomb, Fred L. Homa, Jay C. Brown, Alasdair C. Steven