Iridium‐Catalyzed Regio‐ and Enantioselective N‐Allylation of Indoles
Year: 2009
Type: article
Abstract: Iridium is blind to C: Highly regio- and enantioselective, iridium-catalyzed N-allylations of indoles, which complement the more common reactivity of indoles as carbon nucleophiles, have been developed (see scheme). These reactions form highly enantioenriched N-allylindoles, which are readily transformed into enantioenriched 3-(1H-indol-1-yl)-N-methyl-3-aryl propan-1-amines, dihydropyrrolo[1,2-a]indoles, and indol-1-yl propanoic acids.
Authors: Levi M. Stanley, John F. Hartwig
Institution: University of Illinois Urbana-Champaign
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: Amination and Etherification of Aryl Halides and Olefins, G2223967233, G2225206983, Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S, PALLADIUM CATALYZED FORMATION OF ARYLAMINE AND ARYLETHER, Transition Metal-Catalyzed, Asymmetric Allylic Borylation and Silylation
OpenAlex ID: W2161276602