Year: 2014
Type: review
Abstract: Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.
Source: Integrative Biology
DOI: 10.1039/c4ib00191e
Author: Heiko Enderling
Institution: Moffitt Cancer Center
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,522
OpenAlex ID: W2161302946