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Structural markers in prostate cancer serum imaged ex vivo using cryogenic transmission electron microscopy

Year: 2010

Type: article

Abstract: We used cryogenic transmission electron microscopy (cryo-TEM) to identify differences in macromolecular structures present in the serum from healthy individuals (HI) and prostate cancer (PCa) patients and show that these differences are potential markers for disease. Using a murine orthotopic model of human PCa, we determined that some of these structural markers in serum are associated with the tumour burden. These findings signify the potential of this nanoscale ex vivo imaging technology of body fluids as a platform for discovering early markers of PCa and other diseases.

Source: Journal of Electron Microscopy

DOI: 10.1093/jmicro/dfq019

Authors: N. Aziz, A. K. Jha, C. Thanos, R. Basha, A. Bose

Institutions: University of Rhode Island, University of California, Berkeley

Language: English

Topic: Advanced Electron Microscopy Techniques and Applications

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2161314412

FWCI:

Cites: 17

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Related to: 10