Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation
Year: 1995
Type: article
Abstract: The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.
Source: Journal of Virology
Authors: A P Dackiw, K Zakrzewski, A B Nathens, P Y Cheung, R Fingerote, G A Levy, O D Rotstein
Institution: University of Toronto
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2161671200