Acute and subchronic effects of agmatine on anxiety tested in the elevated plus maze in male mice
Year: 2005
Type: article
Abstract: "Agmatine is an endogenous polyamine, identified in mammalian brain, which meets the main criteriato be considered a neurotransmitter. Agmatine-like immunoreactivity has been described in numerousbrain regions which have long been implicated in the regulation of anxiety. However, animal preclinicalstudies investigating effects of agmatine on anxiety are unclear. In this study, an attempt was madeto clarify the actions of agmatine (7.5-60 mg/kg, ip) on anxiety tested in the elevated plus maze mice.Moreover, the possible development of tolerance to the effects of agmatine on anxiety after itssubchronic administration for 7 consecutive days was also examined. A number of classical parameterswere collected (open arm duration and frequency, closed arm duration and frequency and centralplatform duration and frequency). Different ethological measures were also obtained (rearings, headdippingand stretched attend posture). Results showed that agmatine did not produce any significantbehavioural change in any of the parameters examined, suggesting that it might not be involved in theregulation of anxiety in mice."
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W2161772270