Work

Reliable heritability clustering - finding distinct genetic factors that influence cortical thickness

Year: 2010

Type: conference-paper

Abstract: Introduction Brain imaging phenotypes exhibit extremely high heritability, or h2, with up to 88% of variability in gray matter volume explained by additive genetic factors [1]. In this work we explore the multivariate patterns of heritability. Correlation between any pair of phenotypes is the combination of a genetic and environmental correlation. Hierarchical clustering can be performed using genetic correlations as a distance measure, which will identify brain regions that appear to be influenced by distinct genetic factors.

Source: University of Warwick

DOI: 10.82444/warw.33615724

Authors: R. (Rachel) Walton, Anderson M. Winkler, John Blangero, Peter T. Fox, David C. Glahn, Thomas E. Nichols

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2161783770

FWCI:

Cites: 3

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Related to: 10