Work

An Efficient Fmoc‐SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

Year: 2008

Type: article

Abstract: Intramolecular activation of C-terminal peptides: Mildly activated N-acylurea peptides are readily formed on the solid support following chain assembly, avoiding over-activation of the C-terminus. The utility of these peptides is demonstrated by the native chemical ligation of unprotected peptides (see scheme; R=amino acid side chain).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200705471

Authors: Juan B. Blanco‐Canosa, Philip E. Dawson

Institution: Scripps Research Institute

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Backbone Effects on Protein Stability and Folding