Work

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Induces both a G 2 and a Mitotic Block

Year: 2002

Type: article

Abstract: The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activator that mediates the switch from latent to lytic infection. Here we demonstrate that BZLF1 induces both a G(2) block and a mitotic block in HeLa cells and inhibits chromosome condensation. While the G(2) block is associated with decreased cyclin B1 in host cells and can be rescued by overexpression of cyclin B1, the mechanism for the mitotic defect is as yet undetermined.

Source: Journal of Virology

DOI: 10.1128/jvi.76.19.10030-10037.2002

Authors: Amy Mauser, Elizabeth Holley-Guthrie, Dennis Simpson, William Kaufmann, Shannon Kenney

Institutions: UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute