Work

Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

Year: 2011

Type: article

Abstract: Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid–polymer–lipid nanostructure is elucidated by electron and fluorescence microscopy (right) and provides the delivery system with distinct functional features.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201101554

Authors: Jinjun Shi, Zeyu Xiao, Alexander R. Votruba, Cristian Vilos, Omid C. Farokhzad

Institutions: Brigham and Women's Hospital, Massachusetts Institute of Technology

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering