Adolescent girls’ neural response to reward mediates the relation between childhood financial disadvantage and depression
Year: 2015
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Children who experience socioeconomic disadvantage are at heightened risk for developing depression; however, little is known about neurobiological mechanisms underlying this association. Low socioeconomic status (SES) during childhood may confer risk for depression through its stress-related effects on the neural circuitry associated with processing monetary rewards. METHODS: In a prospective study, we examined the relationships among the number of years of household receipt of public assistance from age 5-16 years, neural activation during monetary reward anticipation and receipt at age 16, and depression symptoms at age 16 in 123 girls. RESULTS: Number of years of household receipt of public assistance was positively associated with heightened response in the medial prefrontal cortex during reward anticipation, and this heightened neural response mediated the relationship between socioeconomic disadvantage and current depression symptoms, controlling for past depression. CONCLUSIONS: Chronic exposure to socioeconomic disadvantage in childhood may alter neural circuitry involved in reward anticipation in adolescence, which in turn may confer risk for depression.
DOI: 10.1111/jcpp.12410
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Defense, U.S. Department of Justice, William T. Grant Foundation, University of California, National Institutes of Health, University of California, Davis, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute on Drug Abuse, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Self-Regulation of Reward in Adolescence, ISRCAP Biennial Meeting, G112045822, G11283329, G1254794811, G1263198668, G1380652875, G144326966, PITTSBURGH GIRLS STUDY: SUBSTANCE USE AND HIV RISK BEHAVIORS/STI IN YOUNG ADULTHOOD, G1533008480, G1731691164, G1742692136, Neurophysiological Risk for Adolescent Social Phobia, G1762593819, Predoctoral Training Consortium in Affective Science, G2264687594, Relationship between adolescent weight, sexual behavior and reproductive outcomes, G2371580590, G2577888639, G2642880704, G2704629129, G274358230, G2748976177, G2755437107, G2848839053, G30541823, An Innovative Approach to Preventing Depression, G3609673307, G3659166747, G3856954409, G391874068, G4016851416, G4086244853, G44449455, G469418026, Impact of Omega-3 Intake During Pregnancy on Maternal Stress and Infant Outcome, G4927824870, G4935735832, Neurobiological Reactivity, Allostatic Load and Depression in Mexican Youth, G5030942808, G5319725938, G5597271579, G6699076719, Reward, pathophysiologic dimensions and psychological distress in young adults, IBSS: Understanding Long-Term Effects on Children in Economic Distress, G7436119673, G7536664249, G7642915562, Role of Romantic Relationships in the Sexual Behavior of Obese and Non-Obese Girl, G820408652, G8276169783, Developmental Changes in Neural Processes Underlying Inattention, Impulsivity and Regulation, G879068113, G8873773716, G9000004100, G9000019272, G9000034074, G9000064271, G9000065142, G9000092861, G9000173296, G9000207192, G9000216450, G9000219662, G9000229112, G9000241011, G9000249007, G9000253744, G9000272428, G9000352390, Reward, impulsive sensation seeking and emotional dysregulation: neural mechanisms underlying risk for bipolar disorder in young adults
OpenAlex ID: W2161945971