Prophylactic efficacy of some antibiotic combinations against Brucella melitensis 16M in BALB/c mice.
Year: 2013
Type: article
Abstract: Summary Safi, M., B. Albalaa & A. AlMariri, 2013. Prophyla ctic efficacy of some antibiotic com� binations against Brucella melitensis 16M in BALB/c mice. Bulg. J. Vet. Med. , 16, No 3, 198 −207. Brucellosis is an endemic zoonosis in Syria, affecting both humans and animals. Data regarding suitable antibiotic combinations in postexposure p rophylaxis against Brucella melitensis infections are rare. Prophylactic effects of some antibiotic combinations were assessed in BALB/c mice, to limit or control infection by B. melitensis 16M. Antibiotics were administrated prior to (for 7 days), after or at the same time as (for 5 days) the bacterial administration. When a concentration of 10 4 CFU of bacteria was injected, doxycyclinerifampicin combi nation reduced the bacterial counts in the spleens of infected mice in all mice groups either 48 h our 30 days after the cessation of antibiotic treatment; whereas, all other combinations had almost good efficacy only 30 days after the cessation of antibiotic treatment. On another hand, only doxycyclinerifampicin and rifampicinlevofloxacin com� binations had good efficacy 48 hours after the cessation of antibiotic treatment, when a concentration of 10 7 CFU of bacteria was injected. In conclusion, these results suggest that doxycyclinerifampicin combination, and may be doxycyclineciprofloxacin arifampicinlevofloxacin combinations, had good prophylactic efficacy against B. melitensis infections and may provide protection against these infections.
Authors: Mazen Safi, B. Al Balaa, Ayman Al-Mariri
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2162224465