Year: 2014
Type: review
Abstract: Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.
Source: Human Molecular Genetics
DOI: 10.1093/hmg/ddu041
Authors: C. T. L. Chen, C.-T. Liu, G. K. Chen, J. S. Andrews, A. M. Arnold, J. Dreyfus, N. Franceschini, M. E. Garcia, K. F. Kerr, G. Li, K. K. Lohman, S. K. Musani, M. A. Nalls, L. J. Raffel, J. Smith, C. B. Ambrosone, E. V. Bandera, L. Bernstein, A. Britton, R. G. Brzyski, A. Cappola, C. S. Carlson, D. Couper, S. L. Deming, M. O. Goodarzi, G. Heiss, E. M. John, X. Lu, L. Le Marchand, K. Marciante, B. Mcknight, R. Millikan, N. L. Nock, A. F. Olshan, M. F. Press, D. Vaiyda, N. F. Woods, H. A. Taylor, W. Zhao, W. Zheng, M. K. Evans, T. B. Harris, B. E. Henderson, S. L. R. Kardia, C. Kooperberg, Y. Liu, T. H. Mosley, B. Psaty, M. Wellons, B. G. Windham, A. B. Zonderman, L. A. Cupples, E. W. Demerath, C. Haiman, J. M. Murabito, A. Rajkovic
Institutions: Fred Hutch Cancer Center, Boston University, Framingham Heart Study, Wake Forest University Health Sciences, Wake Forest University, University of Minnesota, University of North Carolina at Chapel Hill, National Institutes of Health, National Institute on Aging, University of Washington, University of Mississippi Medical Center, University of Michigan, Roswell Park Comprehensive Cancer Center, Rutgers Cancer Institute, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, The University of Texas at San Antonio Health Science Center, University of Pennsylvania, Vanderbilt University, Cedars-Sinai Medical Center, Stanford Medicine, Stanford University, Beth Israel Deaconess Medical Center, University of Hawaiʻi at Mānoa, University of Hawaii System, UNC Lineberger Comprehensive Cancer Center, Case Western Reserve University, University of Southern California, USC Norris Comprehensive Cancer Center, Johns Hopkins University, Kaiser Permanente Washington Health Research Institute, University of Pittsburgh
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G100949702, G1017297203, G1023702118, G1052397333, G1080192134, Women's Health Initiative, Multi-Ethnic Study of Atherosclerosis (MESA) Study, G1186962729, G1220223050, G1243299691, G125972088, Genetic Determinants of Visceral Adiposity, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, JACKSON HEART STUDY, Women's Health Initiative, G1345547317, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, G1462415530, G152041249, G1527150935, G153510172, G1569999668, Women's Health Initiative, CORONARY HEART DISEASE AND STROKE, G164076637, G1691174148, MESA Family Study - Columbia University Field Center, UCLA Clinical and Translational Science Institute, G1727292203, G173303992, Women's Health Initiative, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G2313542652, G2391884931, Institute for Clinical and Translational Research (UL1), G2548880556, G2553282249, MESA Family Study, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G2663518188, G270907595, G2784927490, G2791772408, G2800149121, G2818913090, G2844380389, G297113894, G3007686689, JACKSON HEART STUDY, G3045517347, G3114902838, HEALTH ABC--COORDINATING UNIT, G3186385431, UCLA Clinical and Translational Science Institute, Women's Health Initiative Memory Study (WHIMS), G34347772, G3462919067, G3497998071, Institute for Integration of Medicine & Science: A Partnership to Improve Health, Women's Health Initiative, G36937976, GWA for Gene-Environment Interaction Effects Influencing CHD, CANDIDATE GENE ASSOCIATION RESOURCE (CARE), G3809606526, G3912115555, G395403786, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Women's Health Initiative, Women's Health Initiative, G413560588, G423252844, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, G4296038422, G443607800, G445374210, G4905946337, G49077879, MESA Family Study, MESA Family Study, G5101955913, G5254636657, FOR ALL FIELD CENTER FOR WHI EXTENSION, G5302475043, G536099884, G538503247, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G5479317095, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G560706073, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, G567847597, G573134505, G5755642980, G581887176, G587882820, G5909482378, CHS Events Follow-up Study, G6226795708, Genetics of Reproductive Life Period and Health Outcomes, G670738241, CHS-Transition Phase, Women's Health Initiative, G7176672723, G7223985928, Women's Health Initiative, MESA, G7582705761, G777822606, CHS Events Follow-up Study, Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS), G809566800, G820615960, G8267674335, G831158291, G861947890, G870117454, G870807107, G878552033, G884570035, G9000002220, G9000015938, G9000016408, G9000029166, G9000072420, G9000099044, G9000151586, G9000284018, UNC Center for Environmental Health and Susceptibility, Diabetes Research Center (DRC), From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, G904881343, G905887895, G931818222, G945304896, JACKSON HEART STUDY
OpenAlex ID: W2162230245