Work

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

Year: 2010

Type: article

Abstract: From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201000620

Authors: Richard J. Clark, Jonas Jensen, Simon T. Nevin, Brid P. Callaghan, David J. Adams, David J. Craik

Institutions: The University of Queensland, Institute for Molecular Bioscience, RMIT University

Language: English

Topic: Venomous Animal Envenomation and Studies

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2162291204

FWCI: 24.52

Cites: 29

Cited by: 317

Related to: 10