Year: 2010
Type: erratum
Abstract: Using principal component (PC) analysis, we studied the genetic constitution of 3,112 individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (SNPs) genotyped with the Illumina Infinium platform.In cohorts where the sample size was .100,one hundred randomly chosen samples were used for analysis to minimize the sample size effect, resulting in a total of 1,564 samples.This analysis revealed that the genetic structure of the European population correlates closely with geography.The first two PCs highlight the genetic diversity corresponding to the northwest to southeast gradient and position the populations according to their approximate geographic origin.The resulting genetic map forms a triangular structure with a) Finland, b) the Baltic region, Poland and Western Russia, and c) Italy as its vertexes, and with d) Central-and Western Europe in its centre.Inter-and intra-population genetic differences were quantified by the inflation factor lambda (l) (ranging from 1.00 to 4.21), fixation index (F st ) (ranging from 0.000 to 0.023), and by the number of markers exhibiting significant allele frequency differences in pair-wise population comparisons.The estimated lambda was used to assess the real diminishing impact to association statistics when two distinct populations are merged directly in an analysis.When the PC analysis was confined to the 1,019 Estonian individuals (0.1% of the Estonian population), a fine structure emerged that correlated with the geography of individual counties.With at least two cohorts available from several countries, genetic substructures were investigated in Czech, Finnish, German, Estonian and Italian populations.Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS).
Source: PLoS ONE
Authors: Mari Nelis, Tõnu Esko, Reedik Mägi, Fritz Zimprich, Alexander Zimprich, Draga Toncheva, Sena Karachanak, Tereza Piskáčková, Ivan Balaščák, Leena Peltonen, Eveliina Jakkula, Karola Rehnström, Mark Lathrop, Simon Heath, Pilar Galan, Stefan Schreiber, Thomas Meitinger, Arne Pfeufer, H-Erich Wichmann, Béla Melegh, Noémi Polgár, Daniela Toniolo, Paolo Gasparini, Pio D'Adamo, Janis Klovins, Liene Nikitina-Zake, Vaidutis Kučinskas, Jūratė Kasnauskienė, Jan Lubinski, Tadeusz Debniak, Svetlana Limborska, Andrey Khrunin, Xavier Estivill, Raquel Rabionet, Sara Marsal, Antonio Julià, Stylianos E. Antonarakis, Samuel Deutsch, Christelle Borel, Homa Attar, Maryline Gagnebin, Milan Macek, Michael Krawczak, Maido Remm, Andres Metspalu
Institutions: Estonian Biocentre, University of Tartu, Smithsonian Institution, National Zoological Park, Medical University of Vienna, IRCCS Materno Infantile Burlo Garofolo, Medical University of Sofia, Charles University, University Hospital in Motol, Wellcome Sanger Institute, Institute for Molecular Medicine Finland, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Fondation Jean Dausset-CEPH, Inserm, Institut National de la Recherche Agronomique, University Hospital Schleswig-Holstein, TUM Klinikum, Helmholtz Munich, Institut für Humangenetik, Technical University of Munich, Ludwig-Maximilians-Universität München, University of Pecs, IRCCS Ospedale San Raffaele, University of Trieste, Latvian Biomedical Research and Study Centre, Vilnius University, International Hereditary Cancer Center, Pomeranian Medical University, Russian Academy of Sciences, Institute of Molecular Genetics, Centre for Genomic Regulation, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, University of Geneva
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: National Science Foundation, Compagnia di San Paolo, Univerzita Karlova v Praze, European Commission, Academy of Finland, Bundesministerium für Bildung und Forschung, Ministero della Salute, Ministerstvo Zdravotnictví Ceské Republiky, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Ministerio de Ciencia e Innovación, Ettevõtluse Arendamise Sihtasutus, Tartu Ülikool, Russian Academy of Sciences, European Regional Development Fund, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
OpenAlex ID: W2162320063