Year: 2011
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS: Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were assessed in 3,802 individuals. RESULTS: Total and HMW adiponectin were highly correlated (r = 0.94). Analysis using cubic splines revealed that the associations between total and HMW adiponectin and new-onset diabetes were not linear. Specifically, after adjustment for confounders, there were similar inverse relationships for total (hazard ratio per SD 0.49 [95% CI 0.39-0.63]) and HMW adiponectin (0.42 [0.32-0.56]) with diabetes up to values of 20 and 10 mg/L, respectively, above which the associations plateaued. These associations persisted after adjustment for potential mediators (blood pressure, lipids, C-reactive protein, and homeostasis model assessment of insulin resistance [HOMA-IR]). There was, however, evidence of interaction by HOMA-IR in the lower range of adiponectin, with stronger inverse associations among insulin-sensitive than insulin-resistant participants. HMW-to-total adiponectin ratio showed a linear adjusted association with outcome, but this was abolished by inclusion of mediating variables. CONCLUSIONS: In this older cohort, increasing concentrations of total and HMW adiponectin were associated with comparably lower risks of diabetes, but these associations leveled off with further increases above concentrations of 20 and 10 mg/L, respectively. The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.
Source: Diabetes Care
DOI: 10.2337/dc11-1519
Institutions: Weill Cornell Medicine, University of Washington, University of California San Diego, VA San Diego Healthcare System, Brigham and Women's Hospital, Harvard University, National Institutes of Health, National Institute on Aging, Emory University, University of Vermont, Beth Israel Deaconess Medical Center, VA Boston Healthcare System
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1023702118, G10717269, G1220223050, G1224608327, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1401438683, G1412333385, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1727292203, G1742450553, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, G1890355377, G1909643007, G2125948122, G2194386449, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, Determinants and Cardiovascular Consequences of Diabetes in Older Adults, G236442059, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G274585943, G277826483, G2786044735, G2800149121, G2847759872, G2882309788, G3137375862, G3145043064, G3169706684, G328935669, G3370719899, G34347772, G3507024915, G3560915123, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Predictors of Alheimers Disease in Mild Cognitive Impairment, G4012114008, G4048755144, G423252844, G4987078009, G5167412771, G573134505, CHS Events Follow-up Study, G61834786, G6226795708, Predictors of Alzheimers Disease in Mild Cognitive Impairment, CHS-Transition Phase, G687544517, G693548699, G7035200923, G7286144250, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, G766843672, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G777822606, CHS Events Follow-up Study, G7999488110, G806768229, COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA, G8593276544, G859984287, Hormonal trajectories in aging, G905887895, G936067872, G960597250
OpenAlex ID: W2162366820