Discovery of DNA Polymerase
Year: 2003
Type: article
Abstract: DNA polymerase, an enzyme discovered in 1955, has the remarkable capacity to catalyze the template-directed synthesis of DNA (1, 2). The discovery of DNA polymerase has contributed in major ways to our present day understanding of how DNA is replicated and repaired and how it is transcribed. It also permitted the development of PCR and DNA sequencing, upon which much of modern biotechnology is based. In this article, I wish to recount how the discovery of the first DNA polymerase, DNA polymerase I of Escherichia coli, came about.
Source: Journal of Biological Chemistry
Author: I.R. Lehman
Institution: Stanford University
Language: English
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2162383937