Year: 1989
Type: dissertation
Abstract: This thesis deals with clinically nonfunctioning, ,a-subunit \nsecreting and gonadotroph pituitary adenomas. From the literature \ndiscussed in the preceding chapter several questions arise. \nBelow these questions are listed with a reference to where the \nsubject concerned was mentioned or discussed in the preceding \nchapter, as well as with a reference to the chapter where these \nquestions will be discussed in detail. \n1. (1.2.5) Do all clinically nonfunctioning pituitary adenomas \nrelease gonadotropins and their subunits in vitro? (4,5,6) \n2. (1.2.5) Can the hormone release from clinically nonfunctioning \nadenomas in vitro be suppressed and stimulated with \nhormones and drugs? (5,6) \n3. ( 1. 2. 3, 1. 2. 5) Is the secretory activity of clinically \nnonfunctioning, a-subunit secreting, and gonadotroph adenomas \nbetter reflected in results from cell culture than in results \nfrom immunocytochemistry? (6) \n4. (1.2.1,1.2.5) Are clinically nonfunctioning, a-subunit \nsecreting, and gonadotroph pituitary adenomas to be regarded as \none group? (5,6) \n5. (1.2.4} Is the exaggerated response in serum gonadotropin \nlevels to TRH limited to patients with a gonadotroph adenoma? (5) \n6. (1. 2. 6) can bromocriptine significantly suppress serum \ngonadotropin and a-subunit concentrations in patients with a \nclinically nonfunctioning adenoma and will these patients benefit \nfrom prolonged treatment with bromocriptine? (5,8) \n7. (1.1.2,1.2.2) By analogy with the findings in aging men, \ndo serum estradiol concentrations decrease and gonadotropin \nlevels increase in aging postmenopausal women? (7) \n8. (1.2.6) Can GnRH analogs be beneficial in patients with \ngonadotroph pituitary adenomas? (8) \n9. Which drugs are promising in the future treatment of \ngonadotroph, a-subunit secreting, and clinically nonfunctioning \npituitary adenomas? (8) The major subjects discussed in the various chapters are \nlisted below: An introduction to the literature on clinically nonfunctioning, \na-subunit secreting and gonadotroph pituitary adenomas \nwas given in Chapter 1. \nThe presenting symptoms of these adenomas and some in vivo \ndata are discussed in Chapter 3. \nconfounding factors in the· in vitro research of these adenomas \nare analyzed in Chapter 4. \nThe correlations between in vivo and in vitro hormone data, \neffects of TRH and bromocriptine, and similarities between \ngonadotroph and clinically nonfunctioning adenomas are discussed \nin Chapter 5. \nAdditional in vitro data are presented in Chapter 6. \nThe etiology of clinically nonfunctioning and gonadotroph \nadenomas is discussed in the light of the age-dependent changes \nin gonadotropin and sex steroid levels in normal subjects in \nChapter 7. \nThe role of 2 drugs that might be useful in the therapy of \nclinically nonfunctioning, a-subunit secreting and gonadotroph \npituitary adenomas is discussed in Chapter a. \nA discussion of the major conclusions of this thesis is \npresented in Chapter 9
Author: Dirk Jan Kwekkeboom
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2162385896