Work

Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

Year: 2013

Type: article

Abstract: Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

Source: Journal of Molecular Cell Biology

DOI: 10.1093/jmcb/mjt034

Authors: Shigeo Masuda, Jun Wu, Tomoaki Hishida, Ganesh N. Pandian, Hiroshi Sugiyama, Juan Carlos Izpisua Belmonte

Institutions: Salk Institute for Biological Studies, Kyoto University, Center of Regenerative Medicine in Barcelona

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2162489259